80 Scientific Studies on the Harmful Environmental and Health Effects of Pesticides


Toxicant and Disease Database: The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. https://www.healthandenvironment.org/what-we-do/toxicant-and-disease-database/

Role of Paraoxonase (PON1) Status in Pesticide Sensitivity: Genetic and Temporal Determinants http://www.sciencedirect.com/science/article/pii/S0161813X04001123

Myths of Safe Pesticides http://www.ifoam.bio/sites/default/files/mythsofsafepesticides-summary_web.pdf

A Small Dose of Toxicology: The Health Effects of Common Chemicals, 2nd edition, by Steven G. Gilbert, explores the principles of toxicology by examining the health effects of common chemical agents. http://www.toxipedia.org/display/dose/A+Small+Dose+of+Toxicology

Study of rural New York State Homes finds Pesticides in every sample tested https://beyondpesticides.org/dailynewsblog/2018/10/study-of-rural-new-york-state-homes-finds-pesticides-in-every-sample-tested/

Pesticides in Ambient Air in Alberta http://esrd.alberta.ca/lands-forests/land-industrial/programs-and-services/pesticide-management/documents/Pesticides_in_Ambient_Air_Report.pdf

The unsteady state and inertia of chemical regulation under the US Toxic Substances Control Act http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002404

Pesticide risk assessments seen as biased, experts advise https://www.sciencedaily.com/releases/2014/09/140903121850.htm

A searchable database of MSDS (material safety data sheets) and product labels at a company called Crop Data Management Systems, Inc: http://www.cdms.net/Label-Database

From Wikipedia on MSDS: http://en.wikipedia.org/wiki/Material_safety_data_sheet)

Annual Pesticide Use Maps: 1992-2012 ("Select a pesticide." There are MANY to pick from.) http://water.usgs.gov/nawqa/pnsp/usage/maps/compound_listing.php

County-level pesticide use estimates are available in tabular format http://pubs.usgs.gov/ds/752/--

(USGS) Estimated Annual Agricultural Pesticide Use for Counties of the Conterminous United States, 2008–12 (report available in pdf format) http://pubs.usgs.gov/ds/0907/

THE PPDB Pesticide Properties Database is a comprehensive relational database of pesticide chemical identity, physicochemical, human health, and ecotoxicological data. http://sitem.herts.ac.uk/aeru/ppdb/en/

(USGS) Pesticides in U.S. Streams and Rivers: Occurrence and Trends during 1992-2011

-- (USGS) Pesticide National Synthesis Project http://water.usgs.gov/nawqa/pnsp/usage/maps/index.php

-- (USGS) Estimation of Annual Agricultural Pesticide Use for Counties of the Conterminous United States, 1992–2009 (report available in pdf format) http://pubs.usgs.gov/sir/2013/5009/

-- (USGS) Pesticide Use Maps - Glyphosate http://water.usgs.gov/nawqa/pnsp/usage/maps/show_map.php?year=2012&map=GLYPHOSATE&hilo=L&disp=Glyphosate

-- The Mind, Disrupted Biomonitoring Project - "In 2009, 12 leaders and self-advocates from the learning and developmental disabilities community volunteered to have their bodies tested for 89 chemicals known or suspected of being neurodevelopmental toxicants or endocrine disruptors, including bisphenol A, lead, mercury, organochlorine pesticides, polybrominated diphenyl ethers (PBDEs), perchlorate, perfluorinated compounds (PFCs), and triclosan. 61 chemicals (out of 89 tested) were found in the twelve participants. Each participant was found to harbor at least 26 and as many as 38 of the tested chemicals in their bodies. Sixteen chemicals were detected in every participant." More at http://www.minddisrupted.org/findings.participant.php

-- (Press release 25 Feb 2015) Agricultural insecticides pose a global risk to surface water bodies - The first global map to be produced on potential insecticide contamination: Leipzig/ Landau. Streams within approx. 40% of the global land surface is at risk from applying insecticides. These were the results from the first global map to be modeled on insecticide runoff to surface waters, which has just been published in the journal Environmental Pollution by researchers from the Helmholtz Center for Environmental Research (UFZ) and the University of Koblenz-Landau together with the University of Milan, Aarhus University and Aachen University. According to the publication, particularly streams in the Mediterranean, the USA, Central America, and Southeast Asia are at risk. https://www.ufz.de/index.php?en=33597

-- Agricultural insecticides threaten surface waters on a global scale (Sebastian Stehle and Ralf Schulz), Institute for Environmental Sciences, University Koblenz-Landau, D-76829 Landau, Germany. Edited by Jules M. Blais, University of Ottawa, Ottawa, Canada, and accepted by the Editorial Board March 13, 2015 (received for review January 6, 2015)* http://www.pnas.org/content/112/18/5750.abstract* http://www.pnas.org/content/112/18/5750.full.pdf

PDF of the report from NY State Atty General on the problems with 'inert' ingredients in pesticides http://www.blm.gov/pgdata/etc/medialib/blm/wo/Planning_and_Renewable_Resources/veis/final_eis_vol_3/public_comment_letters/email_comments__emc.Par.12883.File.pdf/EMC0643_Attachment_3%28edit%29.pdf

Exposure and Interaction – The Potential Health Impacts of Using Multiple Pesticides: A Case Study of Three Commonly Used Fumigants. http://www.stpp.ucla.edu/sites/default/files/Exposure_and_Interaction_2016_Summary_Web.pdf

Research finds that low concentrations of pesticides can become a toxic mixture https://phys.org/news/2008-11-pesticides-toxic-mixture.html#nRlv

Unexamined Endocrine Disruption? Pesticides Inhibit Prostaglandin Activity http://ehp.niehs.nih.gov/wp-content/uploads/124/4/ehp.124-A76.alt.pdf

Pesticides and the Immune System https://www.wri.org/publication/pesticides-and-immune-systemStorm-event-transport of urban-use pesticides to streams likely impairs invertebrate assemblages https://pubs.er.usgs.gov/publication/70171081

Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures http://ehp.niehs.nih.gov/ehp129/

National Marine Fisheries Service Endangered Species Act Section 7 Consultation Biological Opinion on Environmental Protection Agency Registration of Pesticides Containing Azinphos methyl, Bensulide, Dimethoate, Disulfoton, Ethoprop, Fenamiphos, Naled, Methamidophos, Methidathion, Methyl parathion, Phorate, and Phosmet http://www.nmfs.noaa.gov/pr/pdfs/final_batch_3_opinion.pdf

US G.A.O. Lawn Care Pesticides: Risks Remain Uncertain While Prohibited Safety Claims Continue http://www.gao.gov/products/RCED-90-134 - not peer-reviewed science, or data but helpful info regarding safety claims and legal aspects of.

Chemicals In Our Waters Are Affecting Humans And Aquatic Life In Unanticipated Ways https://www.sciencedaily.com/releases/2008/02/080216095740.htm

Increasing Use of Pyrethroids in Canadian Households: Should We Be Concerned? http://journal.cpha.ca/index.php/cjph/article/viewFile/3526/2728

Accumulation levels and characteristics of some pesticides in human adipose tissue samples from Southeast China (mortality of malignant tumors tends to associate with the pesticides levels in human adipose tissue [fat].) https://www.ncbi.nlm.nih.gov/pubmed/21722941

Effect of Endocrine Disruptor Pesticides: A Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138025/#!po=6.25000

Pest Smart app to look up pesticide names https://itunes.apple.com/us/app/id976412743

Common insecticides mimic melatonin, creating a higher potential risk for diabetes and metabolic diseases http://www.buffalo.edu/news/releases/2017/01/021.html

DISEASES linked to PESTICIDES (grouped by the strength of evidence) - good site with lots of info (http://www.ehatlas.ca/) http://www.ehatlas.ca/che-search/toxicant/2380

Scientists identify six important shortcomings in the current procedures used to assess pesticide safety http://www.ourstolenfuture.org/NewScience/regulatory/1999porteretal.htm

Toxic Mixtures in Time—The Sequence Makes the Poison (sequence of exposures affect toxicity) http://pubs.acs.org/doi/abs/10.1021/acs.est.6b06163#.WKyQjWFmQS8.twitter

Effects of pesticide mixtures in human and animal models: An update of the recent literature http://www.sciencedirect.com/science/article/pii/S0009279716302198

Endocrine-disrupting chemicals (EDCs) deplete glutathione (an important detoxifying antioxidant) leading to worsening inflammation in airways of mice (asthma) http://onlinelibrary.wiley.com/doi/10.1002/eji.200535140/pdf

Pyrethroid concentrations and persistence following indoor application - 70% of cypermethrin, a pyrethroid pesticide found in up to 90% of homes, still found in dust samples around the house after one year https://www.eurekalert.org/pub_releases/2017-06/soet-bsa062217.php

Occupational pesticide exposure linked to fixed airflow obstruction and chronic bronchitis http://www.clinicaladvisor.com/copd-information-center/fixed-airflow-obstruction-increases-with-occupational-exposure-to-pesticides/article/681023/

Neonics exhibiting endocrine disruption - effects of neonicotinoids on aromatase (enzyme that produces estrogen) activity and hormone production http://www.sciencedirect.com/science/article/pii/S0041008X17303150

Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides https://www.sciencedirect.com/science/article/pii/S221475001730149X

Ignoring Adjuvant Toxicity Falsifies the Safety Profile of Commercial Pesticides https://www.frontiersin.org/articles/10.3389/fpubh.2017.00361/full

The Lancet Commission on pollution and health http://www.thelancet.com/commissions/pollution-and-health

2008–2009 Annual Report - President’s Cancer Panel REDUCING ENVIRONMENTAL CANCER RISK What We Can Do Now https://deainfo.nci.nih.gov/advisory/pcp/annualreports/pcp08-09rpt/pcp_report_08-09_508.pdf

Commercial pesticides: Not as safe as they seem https://www.sciencedaily.com/releases/2018/03/180308120621.htm

Nonmonotonic Dose-Response Curves Occur in Dose Ranges That Are Relevant to Regulatory Decision-Making https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137554/

Flaws in industry-funded pesticide evaluation. https://www.eurekalert.org/pub_releases/2018-11/ki-fii111318.php

Pesticide residue builds up in soil - European study https://www.zmescience.com/science/pesticide-build-ups-are-contaminating-europes-fields/


Stronger pesticide regulations are likely needed to protect all bee species, say studies: https://www.sciencedaily.com/releases/2018/12/181211122501.htm

Pesticide exposure raises the risk for cardiovascular disease among Latino workers: https://www.eurekalert.org/pub_releases/2018-12/uoia-per121218.php

Advancements in Life Cycle Human Exposure and Toxicity Characterization: https://ehp.niehs.nih.gov/doi/10.1289/EHP3871

Pesticide exposure contributes to faster ALS progression: https://www.sciencedaily.com/releases/2019/02/190228093553.htm

California state and county officials falling short in evaluating the use of agricultural pesticides: https://phys.org/news/2019-03-california-state-county-falling-short.html

Chemical mixtures pose an ‘underestimated’ risk to human health, says, scientists: https://horizon.scienceblog.com/813/chemical-mixtures-pose-underestimated-risk-to-human-health-say-scientists/

The USA lags behind other agricultural nations in banning harmful pesticides: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0488-0

Biting backfire: Some mosquitoes actually benefit from pesticide application: https://phys.org/news/2019-06-backfire-mosquitoes-benefit-pesticide-application.html

Pesticide Exposure Linked to Teen Depression in Agricultural Communities: https://health.ucsd.edu/news/releases/Pages/2019-07-02-pesticide-exposure-linked-to-teen-depression-in-ag-communities.aspx

Three billion birds have been lost in North America since 1970



45% higher risk of heart disease or stroke in those with high pesticide exposure (pesticide applicators at risk): https://medicalxpress.com/news/2019-09-pesticide-exposure-heart-disease.html

Common Fungicides’ Use Leads To Algae Blooms: https://beyondpesticides.org/dailynewsblog/2019/10/common-fungicides-indirectly-lead-to-algae-blooms/

Pesticide companies leverage regulations for financial gains https://phys.org/news/2019-10-pesticide-companies-leverage-financial-gains.html

School of Medicine and Health Sciences report outlining information for physicians to help patients avoid and lessen exposure to pesticides, lead, and mercury, associated with brain development and pregnancy complications. https://www.ncbi.nlm.nih.gov/pubmed/31378288

Researchers develop a model for a more realistic risk assessment of pesticides: https://phys.org/news/2019-10-realistic-pesticides.html

Long-Term Insecticide Exposure Tied to Heart Disease - Pyrethroids in mosquito repellents, pet sprays, and lice shampoos may increase cardiovascular risks: https://www.nytimes.com/2019/12/30/well/live/pyrethrin-insecticide-pesticide-heart-disease-cardiovascular-death.html

Association of urinary metabolites of organophosphate and pyrethroid insecticides and phenoxy herbicides with endometriosis: https://www.sciencedirect.com/science/article/pii/S0160412019341947?via%3Dihub#bi005

Pesticide testing is flawed—and it’s harming our birds and bees: https://www.popsci.com/story/environment/pesticide-regulation-not-good-enough/

The association between pesticide use and cutaneous melanoma: A systematic review and meta‐analysis: https://www.mdlinx.com/journal-summaries/melanoma-melanoma/2020/03/31/7635664/?spec=dermatology

Persistent organic pollutant exposure and celiac disease: A pilot study: https://www.sciencedirect.com/science/article/abs/pii/S0013935120303327?via%3Dihub

Environmental contaminants alter the gut microbiome, health

"Chemicals such as bisphenols, phthalates, some pesticides, persistent organic pollutants, and heavy metals can alter hormone metabolism and are associated with adverse health outcomes."


Milkweed, the only food source for monarch caterpillars, is ubiquitously contaminated

64 pesticide residues were found in milkweed, the west's main food for monarch butterflies. Milkweed samples from all locations studied in California’s Central Valley were contaminated with pesticides, sometimes at levels harmful to monarchs and other insects.


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